alexa Surviving at a distance: organ specific metastasis.


Medicinal Chemistry

Author(s): Obenauf AC, Massagu J

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Abstract The clinical manifestation of metastasis in a vital organ is the final stage of cancer progression and the main culprit of cancer related mortality. Once established, metastasis is devastating, yet only a small proportion of the cancer cells that leave a tumor succeed at infiltrating, surviving, and ultimately overtaking a distant organ. The bottlenecks that challenge cancer cells in newly invaded microenvironments are organ specific and consequently demand distinct mechanisms for metastatic colonization. Here we review the metastatic traits that allow cancer cells to colonize distinct organ sites.
This article was published in Trends Cancer and referenced in Medicinal Chemistry

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