alexa Switching stable patients with schizophrenia from depot and oral antipsychotics to long-acting injectable risperidone: efficacy, quality of life and functional outcome.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Lloyd K, Latif MA, Simpson S, Shrestha KL, Lloyd K, Latif MA, Simpson S, Shrestha KL

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Abstract OBJECTIVE: This international, non-randomised study evaluated maintained efficacy and safety of Risperidone Long-Acting Injectable (RLAI) compared to previous medications. To investigate the possible effect of differences in national health care systems across Europe, the UK subset efficacy, health-related quality of life (HRQoL) and functioning data are reported here. METHODS: Patients with schizophrenia or other psychotic disorders, symptomatically stable on antipsychotic medication, received intramuscular injections of RLAI 25 mg (to a maximum of 50 mg) every 2 weeks for 6 months. RESULTS: Of 182 UK patients recruited; 79\% had schizophrenia (87\% paranoid), 21\% other psychotic disorders; 96\% had been hospitalised at sometime. Improvement in mean Positive and Negative Syndrome Scale (PANSS) total score was significant at 1 month through to endpoint (p = 0.0001). There were significant improvements in PANSS subscales (p
  • DOI: 10.1002/hup.1108
  • This article was published in Hum Psychopharmacol and referenced in Journal of AIDS & Clinical Research

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