alexa Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality.
Oncology

Oncology

Journal of Carcinogenesis & Mutagenesis

Author(s): Sharon M, Mao H, Boeri Erba E, Stephens E, Zheng N,

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Abstract The COP9 signalosome (CSN) is an eight-subunit protein complex that is found in all eukaryotes. Accumulating evidence indicates its diverse biological functions that are often linked to ubiquitin-mediated proteolysis. Here we applied an emerging mass spectrometry approach to gain insight into the structure of the CSN complex. Our results indicate that the catalytically active human complex, reconstituted in vitro, is composed of a single copy of each of the eight subunits. By forming a total of 35 subcomplexes, we are able to build a comprehensive interaction map that shows two symmetrical modules, Csn1/2/3/8 and Csn4/5/6/7, connected by interactions between Csn1-Csn6. Overall the stable modules and multiple subcomplexes observed here are in agreement with the "mini-CSN" complexes reported previously. This suggests that the propensity of the CSN complex to change and adapt its subunit composition might underlie its ability to perform multiple functions in vivo. This article was published in Structure and referenced in Journal of Carcinogenesis & Mutagenesis

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