alexa Synchronous dual primary ovarian and endometrial carcinomas.


Journal of Addiction Research & Therapy

Author(s): Pearl ML, Johnston CM, Frank TS, Roberts JA

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Abstract OBJECTIVES: The synchronous occurrence of carcinoma confined to the ovary and endometrium presents a diagnostic and therapeutic dilemma. These tumors have been variously staged as FIGO Stage IIA ovarian carcinoma, Stage III endometrial carcinoma, or synchronous dual primary carcinomas. Accumulating evidence suggests such patients have a favorable outcome. This retrospective study was undertaken to review our experience with these fascinating tumors. METHODS: The clinical records and the pathologic findings of 16 patients with synchronous dual primary ovarian and endometrial carcinomas were reviewed. RESULTS: The median age was 51 years. Abnormal uterine bleeding was the most common presenting symptom (70\%). All patients had Stage I ovarian and endometrial carcinomas. Fourteen patients (88\%) had endometrioid carcinoma in both sites, while two patients (12\%) had dissimilar histology. For 15 patients (94\%), the grade of both tumors was identical. Only three (19\%) patients had myometrial invasion, with less than 50\% involvement in each case. All patients underwent surgical staging, 11 (70\%) of whom received adjuvant radiation or chemotherapy. The five patients treated with surgery alone had Grade 1 endometrioid tumors. The only relapse occurred in a patient with a clear cell component in both sites. No patient has died of disease. CONCLUSIONS: Patients with synchronous dual primary carcinomas appear to have a more favorable prognosis than that expected with Stage IIA ovarian or Stage III endometrial carcinoma (100\% vs. 63\% or 42\% survival at 3 years, respectively). The excellent survival for patients with Grade 1 dual endometrioid tumors treated with surgery alone suggests that adjuvant therapy may not be necessary for this sub-group.
This article was published in Int J Gynaecol Obstet and referenced in Journal of Addiction Research & Therapy

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