alexa Synergy of arbekacin-based combinations against vancomycin hetero-intermediate Staphylococcus aureus
Oncology

Oncology

Chemotherapy: Open Access

Author(s): Lee JY, Oh WS, Ko KS, Heo ST, Moon CS

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This study was undertaken to evaluate the in vitro activities of arbekacin-based combination regimens against vancomycin hetero-intermediate Staphylococcus aureus (hetero-VISA). Combinations of arbekacin with vancomycin, rifampin, ampicillin-sulbactam, teicoplanin, or quinupristin-dalfopristin against seven hetero-VISA strains and two methicillin-resistant S. aureus strains were evaluated by the time-kill assay. The combinations of arbekacin with vancomycin, teicoplanin, or ampicillin-sulbactam showed the synergistic interaction against hetero-VISA strains. Data suggest that these arbekacin-based combination regimens may be useful candidates for treatment options of hetero-VISA infections.

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This article was published in J Korean Med Sci. and referenced in Chemotherapy: Open Access

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