alexa Syntheses of procyanidin B2 and B3 gallate derivatives using equimolar condensation mediated by Yb(OTf)3 and their antitumor activities.


Organic Chemistry: Current Research

Author(s): Suda M, Katoh M, Toda K, Matsumoto K, Kawaguchi K,

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Abstract Synthesis of procyanidin B2 and B3 gallate derivatives, 3-O-gallate, 3"-O-gallate, and 3,3"-di-O-gallate, were synthesized using equimolar condensation mediated by Yb(OTf)3. Synthesized compounds showed significant antitumor effects against human prostate PC-3 cell lines. Their activities were weaker than well-known EGCG and prodelphinidin B3. Copyright © 2013 Elsevier Ltd. All rights reserved. This article was published in Bioorg Med Chem Lett and referenced in Organic Chemistry: Current Research

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