alexa Synthesis, analgesic and anti-inflammatory evaluation of some new 3H-quinazolin-4-one derivatives.
Medicine

Medicine

Drug Designing: Open Access

Author(s): Alafeefy AM, Kadi AA, ElAzab AS, AbdelHamide SG, Daba MH

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Abstract In this study, we have synthesized a series of 3H-quinazolin-4-ones in order to obtain new compounds with potential analgesic and anti-inflammatory activity. The structures of the newly synthesized compounds were confirmed by means of infrared, nuclear magnetic resonance and mass spectroscopy. Some compounds were evaluated for their analgesic and anti-inflammatory activities by writhing and carrageenan-induced rat paw edema tests, respectively. In comparison to the standard drug indomethacine, compounds 4, 6c, 12-14, 16, 18, 19, and 22 induced significant reduction in the writhing response while compounds 6c, 12, 14, 16, 18, and 22 produced a good dose-dependent anti-inflammatory activity. The best dual analgesic / anti-inflammatory relative activity was observed with compounds 6c, 14, 16, 18, and 22. This article was published in Arch Pharm (Weinheim) and referenced in Drug Designing: Open Access

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