alexa Synthesis, analgesic and anti-inflammatory evaluation of some novel quinazoline derivatives.
Chemistry

Chemistry

Medicinal Chemistry

Author(s): Alafeefy AM, Kadi AA, AlDeeb OA, ElTahir KE, AlJaber NA

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Abstract Two series of some new 2,4,6-trisubstituted-quinazoline derivatives were prepared and screened for their analgesic, anti-inflammatory activity and acute toxicity. Four compounds were more potent analgesic agents than the reference drug Indomethacin and thirteen compounds showed significant anti-inflammatory activity. Seven compounds showed combined ability to inhibit both pain and inflammation. Compounds tested for acute toxicity showed no toxic symptoms or mortality rates 24 h post-administration implying their good safety margin. Copyright © 2010 Elsevier Masson SAS. All rights reserved. This article was published in Eur J Med Chem and referenced in Medicinal Chemistry

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