Author(s): Mahaney PE, Webb MB, Ye F, Sabatucci JP, Steffan RJ,
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Abstract The anti-inflammatory activity of non-selective estrogens has been attributed to their ability to antagonize the activity of nuclear factor kappaB (NF-kappaB), a known mediator of inflammatory responses. Here we report the identification of a potent new class of pathway-selective ER ligands that selectively antagonize NF-kappaB functional activity, while exhibiting a lack of classical estrogenic effect.
This article was published in Bioorg Med Chem
and referenced in Medicinal Chemistry