alexa Synthesis and antimycobacterial activity of pyrazine and quinoxaline derivatives.


Organic Chemistry: Current Research

Author(s): Seitz LE, Suling WJ, Reynolds RC

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Abstract A series of pyrazine and quinoxaline derivatives have been synthesized, and their activity against M. tuberculosis (Mtb) and Mycobacterium avium (MAC) are reported. The 4-acetoxybenzyl ester of pyrazinoic acid and 4'-acetoxybenzyl 2-quinoxalinecarboxylate showed excellent activity against Mtb (MIC ranges of less than 1-6.25 microg/mL) but only modest activity against MAC (MICs of 4-32 microg/mL).
This article was published in J Med Chem and referenced in Organic Chemistry: Current Research

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