alexa Synthesis and antioxidant properties of some novel benzimidazole derivatives on lipid peroxidation in the rat liver.
Chemical Engineering

Chemical Engineering

Journal of Chemical Engineering & Process Technology

Author(s): Ku C, AyhanKilcigil G, Can Eke B, Ican M

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Abstract Some benzimidazole derivatives namely 1-[(substituted thiocarbamoylhydrazine carbonyl) methyl]-2-phenyl-1H-benzimidazoles (1a-13a), N-[(2-phenylbenzimidazol-1-yl methyl)-[1,3,4]-thiadiazole-2-yl]-substituted phenyl amines (1b-13b) and 5-(2-phenyl benzimidazol-1-yl-methyl)-4-substituted phenyl-4H-1,2,4-triazole-3-thiones (1c-13c) were synthesized, and their in vitro effects on the rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels were determined. The most active compound 10a caused an 84\% inhibition of LP at 10(-3) M, which is better than that of butylated hydroxytoluene (BHT) (65\%).
This article was published in Arch Pharm Res and referenced in Journal of Chemical Engineering & Process Technology

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