alexa Synthesis and biological activity of amide derivatives of nimbolide.


Journal of Addiction Research & Therapy

Author(s): Sastry BS, Suresh Babu K, Hari Babu T, Chandrasekhar S, Srinivas PV,

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Abstract Nimbolide (1), a limonoid isolated from Azadirachta indica, is the chief cytotoxic principle in Neem leaves extract. Using nimbolide as a lead compound for anti-cancer analogue design, a series of nimbolide derivatives have been synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 10 compounds screened 2g, 2h and 2i showed potent activity. This article was published in Bioorg Med Chem Lett and referenced in Journal of Addiction Research & Therapy

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