alexa Synthesis and biological activity of new arenediyne-linked isoxazolidines.


Medicinal chemistry

Author(s): Romeo R, Navarra M, Giofr SV, Carnovale C, Cirmi S,

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Abstract Arenediyne-isoxazolidine conjugates have been synthesized as a new scaffold for the development of bioactive mimics. Some of the synthesized compounds are endowed with antiproliferative activity against three human cancer cell lines. Their thermal reactivity suggests that the biological activity probably could not be linked to the Bergman cyclization. Copyright © 2014 Elsevier Ltd. All rights reserved. This article was published in Bioorg Med Chem and referenced in Medicinal chemistry

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