alexa Synthesis and biological evaluation of some new quinazolin-4(3H)-ones derivatives as anticonvulsants
Microbiology

Microbiology

Journal of Chemical Biology & Therapeutics

Author(s): Deepak Gupta, Rajiv Kumar, Ram Kumar Roy, Adish Sharma, Israr Ali, Md Shamsuzzaman

Abstract Share this page

Epilepsy is the most common neurological disorder known, affecting around 1 % of the world’s population, characterized by recurrent seizure attack. A new series of 2-phenyl-3-(3-(substituted-benzylideneamino)-quinazolin-4(3H)-one derivatives (6a–h) was synthesized through condensation of anthranilic acid (1) and benzoyl chloride to give 2-phenyl-benzo[d][1,3]oxazin-4-one (2). Compound 2 was refluxed with hydrazine hydrate and yielded intermediate 3. Further, the intermediate 3 was dehydrated with catalytic amount of GAA and yielded 3-amino-2-phenyl-1H-quinazolin-4-one (4). Compound 4 was further treated with 3-hydroxy benzaldehyde and small amount of GAA to afford schiff base derivative 5. Finally, the Schiff base was treated with various alkyl halide to provide desired compounds 6a–h and structures of the final compounds were confirmed on the basis of their FTIR, NMR, and Mass spectral data. Anticonvulsant activity was evaluated by the maximal electroshock test, further their minimum motor impairment and CNS depressant effect were evaluated by the rotorod motor impairment and Porsolt’s force swim tests, respectively. The results showed that 2-phenyl-3-(3-(propoxybenzylideneamino)-3H-quinazolin-4-one (6c) is the most promising compound with the lowest side effects.

  • To read the full article Visit
  • Subscription
This article was published in Medicinal Chemistry Research and referenced in Journal of Chemical Biology & Therapeutics

Relevant Expert PPTs

Relevant Speaker PPTs

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords