alexa Synthesis and biological properties of 5-(1H-1,2,3-triazol-4-yl)isoxazolidines: a new class of C-nucleosides.
Chemistry

Chemistry

Medicinal Chemistry

Author(s): Giofr SV, Romeo R, Carnovale C, Mancuso R, Cirmi S,

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Abstract A novel series of C-nucleosides, featuring the presence of a 1,2,3-triazole ring linked to an isoxazolidine system, has been designed as mimetics of the pyrimidine nucleobases. An antiproliferative effect was observed for compounds 17a and 17b: the growth inhibitory effect reaches the 50\% in HepG2 and HT-29 cells and increases up to 56\% in the SH-SY5Y cell line after 72 h of incubation at a 100 µM concentration. This article was published in Molecules and referenced in Medicinal Chemistry

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