alexa Synthesis and characteristics of chitin and chitosan with the (2-hydroxy-3-trimethylammonium)propyl functionality, and evaluation of their antioxidant activity in vitro.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Developing Drugs

Author(s): Zhang X, Geng X, Jiang H, Li J, Huang J

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Abstract Quaternary amino groups were introduced into chitin and chitosan to obtain O-(2-hydroxy-3-trimethylammonium)propyl chitin (OHT-chitin) and N-(2-hydroxy-3-trimethylammonium)propyl chitosan (NHT-chitosan). They were characterized by FTIR spectra, and GPC. The molecular weight Mw of OHT-chitin and NHT-chitosan were 8986 and 9723 with polydispersity of 1.01 and 1.0 2, respectively. Their antioxidant activities in vitro were further studied. It was found that β-carotene-linoleic acid values of OHT-chitin and NHT-chitosan at 0.8 mg/mL were up to 91\% and 96\%, while that of chitosan was 40\%. Based on photobleaching of α,α-diphenyl-β-picrylhydrazyl (DPPH) at 326 nm, the DPPH inhibitory activity of OHT-chitin and NHT-chitosan was 30.9\% and 31.9\% at 5 mg/mL, whereas chitosan only gave 4.8\%. It was also exhibited that OHT-chitin and NHT-chitosan had better antioxidant activity than chitosan according to the reducing power as well as H2O2 scavenging activity. Copyright © 2012 Elsevier Ltd. All rights reserved. This article was published in Carbohydr Polym and referenced in Journal of Developing Drugs

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