Author(s): Ardeshir Khazaei, Davood Soudbar, Minoo Sadri, Seyed Mohammad Seyed Mohaghegh
Anew controlled release compound was prepared by the reaction of p-styrene sulphonyl chloride and 8-hydroxyquinoline in the presence of triethylamine as catalyst. The obtained monomer with bioactive agent moiety was polymerized with benzoyl peroxide as initiator at reflux condition under nitrogen atmosphere. The resulting monomer and polymer were identified by spectroscopic methods (FTIR, 1H NMR). Also molecular weight of the polymer was determined by gel permeation chromatography (GPC) and Td was identified by differential scanning calorimetry (DSC), for reason of the existence of aromatics and sulphonate groups in the polymer thermal resistance is high and before temperature reaches its melting point, the degradation of polymer occurs. The release characteristics of the polymer were studied in neutral, alkaline, and acidic media. The hydrolysis data showed that release rates are strongly dependent on the pH of the medium, and the temperature.