alexa Synthesis and free radical scavenging activity of a novel metabolite from the fungus Colletotrichum gloeosporioides.


Journal of Microbial & Biochemical Technology

Author(s): FemenaRos M, GarcaPajn CM, HernndezGaln R, MacasSnchez AJ, Collado IG

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Abstract A novel metabolite (-)-1 was isolated as its peracetylated derivative, (-)-2-(3',4'-diacetoxyphenyl)-3,4-diacetoxytetrahydrofuran (2), from a strain of the phytopathogenic fungus Colletotrichum gloeosporioides CECT 20122. The synthesis of (-)-1 was carried out by ring-closing metathesis of diene 6 and stereoselective dihydroxylation of a dihydrofuran derivative 7 as key steps. The tetraol (-)-1 showed free radical scavenging activity comparable to that of BHT, caffeic acid or protocatechuic acid. This article was published in Bioorg Med Chem Lett and referenced in Journal of Microbial & Biochemical Technology

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