Author(s): Girisha KS, Kalluraya B, Narayana V, Padmashree
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Abstract A series of 1-acetyl/propyl-3-aryl-5-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-pyrazolines were synthesized in one step by condensing suitably substituted propenones, hydrazine and acetic/propionic acid. The newly synthesized pyrazolines were characterized by analytical and spectral data. The new compounds were screened for analgesic and anti-inflammatory activity and most of them showed good activity comparable with that of standard drugs Pentazocin and Diclofinac sodium respectively. Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
This article was published in Eur J Med Chem
and referenced in Medicinal Chemistry