alexa Synthesis and pharmacological study of 1-acetyl propyl-3-aryl-5-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-pyrazoline.
Chemistry

Chemistry

Medicinal Chemistry

Author(s): Girisha KS, Kalluraya B, Narayana V, Padmashree

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Abstract A series of 1-acetyl/propyl-3-aryl-5-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-pyrazolines were synthesized in one step by condensing suitably substituted propenones, hydrazine and acetic/propionic acid. The newly synthesized pyrazolines were characterized by analytical and spectral data. The new compounds were screened for analgesic and anti-inflammatory activity and most of them showed good activity comparable with that of standard drugs Pentazocin and Diclofinac sodium respectively. Copyright (c) 2010 Elsevier Masson SAS. All rights reserved. This article was published in Eur J Med Chem and referenced in Medicinal Chemistry

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