alexa Synthesis, characterization, and antitumor activity of poly (maleic anhydride-co-vinylacetate-co-acrylic acid),


Research & Reviews: Journal of Microbiology and Biotechnology

Author(s): Hatice Kaplan Can

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The ternary copolymerization of maleic anhydride (MA), vinyl acetate (VA), and acrylic acid (AA) [P(MA-co-VA-co-AA)], which is considered to be an acceptor–donor–acceptor system, was carried out in 1,4-dioxane with benzoyl peroxide as an initiator at 70°C under a nitrogen atmosphere. Constants of complex formation for the monomer systems in the study were determined by UV–visible (hydrogen-bonding complex) and 1H-NMR (charge transfer complex) methods, respectively. The results show that polymerization of the P(MA-co-VA-co-AA) system proceeds by an alternating terpolymerization mechanism. It is shown that the synthesized copolymers have typical polyelectrolyte behavior, ability for reversible hydrolysis–anhydrization reactions, and semicrystalline structures. In these cases, including radical polymerization, and formation of semicrystalline structures, the hydrogen-bonding effect plays a significant role. The in vitro cytotoxicities of the synthesized terpolymer and alternating copolymer were evaluated using Raji cells (human Burkitt lymphoma cell line). The antitumor activities of prepared anion-active copolymers were studied using methyl–thiazol–tetrazolium colorimetric assay and 50% of the cytotoxic dose of each copolymer and terpolymer were calculated. Hydrolyzed P(MA-co-VA-co-AA) and P(MA-alt-AA) copolymers have sufficiently high antitumor activity, which depends on the amount of hydrogen-bonding carboxylic groups and their regular distribution in the side chain of functional macromolecules. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 100: 3425–3432, 2006

This article was published in J Appl Polym Sci and referenced in Research & Reviews: Journal of Microbiology and Biotechnology

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