alexa Synthesis, characterization, interaction with DNA and cytotoxicity in vitro of the complexes [M(dmphen)(CO3)].H2O [M=Pt(II), Pd(II)].


Cancer Medicine & Anti Cancer Drugs

Author(s): Gao EJ, Wang L, Zhu MC, Liu L, Zhang WZ

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Abstract The complexes [Pt(dmphen)CO3].H2O (1), [Pd(dmphen)CO3].H2O (2) (dmphen is 2,9-dimethyl-1,10-phenanthroline) have been synthesized and characterized. The binding of the complexes with FS-DNA was investigated by UV spectrum and fluorescence spectrum, showing that the complexes have the ability of interaction with DNA of intercalative mode. The intrinsic binding constant K of the complexes with FS-DNA is 1.8 x 10(5) M(-1) (1) and 1.6 x 10(4) M(-1) (2), respectively. Gel electrophoresis assay demonstrated the ability of the complexes to cleave the pBR 322 plasmid DNA. Evaluation of cytotoxic activity of the complexes against four different cancer cell lines proved that the complexes exhibited cytotoxic specificity and significant cancer cell inhibitory rate. Crown Copyright 2009. Published by Elsevier Masson SAS. All rights reserved. This article was published in Eur J Med Chem and referenced in Cancer Medicine & Anti Cancer Drugs

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