alexa Synthesis, characterization of chitosans and fabrication of sintered chitosan microsphere matrices for bone tissue engineering.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Molecular and Genetic Medicine

Author(s): AbdelFattah WI, Jiang T, ElBassyouni GelT, Laurencin CT

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Abstract The objective of the present study was to synthesize and characterize chitosans with different degrees of deacetylation (DDA\%), prepare chitosan microspheres with controlled chemistry and geometry, and fabricate three-dimensional (3-D) chitosan matrices based on microspheres with appropriate pore size, porosity and mechanical properties suitable for bone tissue engineering applications. Chitosans with three DDA\% of 69\%, 79\% and 97\% were obtained using a thermomechanochemical technique by varying the applied pressure and NaOH solution concentration. The prepared chitosans were comprehensively characterized by proton nuclear magnetic resonance, elemental analysis, viscosity measurements, thermal analyses and X-ray diffraction. In addition, chitosan microspheres were prepared using an ionotropic gelation method. Three-dimensional chitosan matrices were fabricated via a sintered microsphere technique. Scanning electron microscopy revealed rough surfaces of the prepared chitosan microspheres. Mercury intrusion porosimetry revealed a porosity of 19.2\% and a median pore diameter of 199.62microm of the fabricated 3-D matrix. The compressive modulus of the sintered microsphere matrix (662.26+/-54.53MPa) was in the range of human cancellous bone (10-2000MPa), making it suitable for bone tissue engineering applications. This article was published in Acta Biomater and referenced in Journal of Molecular and Genetic Medicine

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