alexa Synthesis of [1,2,4]Oxadiazolo[4,5-a]thiazolo[2,3-b]pyrimidin-9(10H)-ones via 1,3-Dipolar Cycloaddition of Nitrile Oxide to Thiazolo[3,2-a]pyrimidin-3-one Derivatives


Biochemistry & Analytical Biochemistry

Author(s): Xiaofang Li, Aiting Zheng

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A new class of [1,2,4]oxadiazolo[4,5-a]thiazolo[2,3-b]pyrimidin-9(10H)-one was prepared in moderate yields by the reaction of nitrile oxide with 2-arylmethylidene-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-one. The reaction site of dipolarphile is the C[DOUBLE BOND]N of thiazolo[3,2-a]pyrimidin-3-one rather than the expected C[DOUBLE BOND]C of arylmethylidene. The structures of the products were characterized thoroughly by IR, elemental analysis, MS, and NMR analysis.

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This article was published in wiley online library and referenced in Biochemistry & Analytical Biochemistry

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