alexa Synthesis of 1H-1,2,3-triazole linked β-lactam-isatin bi-functional hybrids and preliminary analysis of in vitro activity against the protozoal parasite Trichomonas vaginalis.
Mathematics

Mathematics

Journal of Applied & Computational Mathematics

Author(s): Raj R, Singh P, Haberkern NT, Faucher RM, Patel N, , Raj R, Singh P, Haberkern NT, Faucher RM, Patel N,

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Abstract Twenty-two different triazoles were prepared to examine the anti-Trichomonas vaginalis structure-activity relationships (SAR) within the β-lactam-isatin-triazole conjugate family. The compounds were synthesized by copper-catalyzed 'click chemistry.'In vitro activity against T. vaginalis was determined at 10 and 100 μM for each compound, with eighteen of the synthesized hybrids showing 100\% growth inhibition at 100 μM. The compound 5i, with no cytotoxicity on cultured CHO-K1 cells, is considered a good compound for further analysis. Copyright © 2013 Elsevier Masson SAS. All rights reserved. This article was published in Eur J Med Chem and referenced in Journal of Applied & Computational Mathematics

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