Author(s): Pizzo C, Saiz C, Talevi A, Gavernet L, Palestro P,
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Abstract A series of 18 novel 2-hydrazolyl-4-thiazolidinones-5-carboxylic acids, amides and 5,6-α,β-unsaturated esters were synthesized, and their in vitro activity on cruzipain and T. cruzi epimastigotes was determined. Some agents show activity at 37 μm concentration in the enzyme assay. Computational tools and docking were used to correlate the biological response with the physicochemical parameters of the compounds and their cruzipain inhibitory effects. © 2011 John Wiley & Sons A/S.
This article was published in Chem Biol Drug Des
and referenced in Journal of Developing Drugs