alexa Synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-one thione-5-one derivatives and evaluation as antibacterials.
Chemistry

Chemistry

Organic Chemistry: Current Research

Author(s): Kidwai M, Saxena S, Khan MK, Thukral SS

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Abstract A novel, ecofriendly, one pot solvent free method for the synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-one/thione-5-one derivatives is described which devoids the use of any organic solvents and auxiliaries. All the synthesized compounds were screened for their in vitro antibacterial activity against standard strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. This article was published in Eur J Med Chem and referenced in Organic Chemistry: Current Research

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