alexa Synthesis of 4′-C-fluoromethylnucleosides as potential antineoplastic agents


Journal of Antivirals & Antiretrovirals

Author(s): Kenji Kitano

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2-Deoxy-d-erythro-, ribo-, and arabino-pentofuranosylcytosines, which have a fluoromethyl group at the 4′-position, were synthesized. Introduction of fluorine was achieved by DAST treatment of Full-size image (<1 K), the key intermediate of 4′-C-methylnucleosides. Among these nucleosides, the 2′-deoxy derivative exhibited potent antineoplastic activity in vitro.

This article was published in Tetrahedron and referenced in Journal of Antivirals & Antiretrovirals

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