alexa Synthesis of 4-pyrido-6-aryl-2-substituted amino pyrimidines as a new class of antimalarial agents.
Chemical Engineering

Chemical Engineering

Mass Spectrometry & Purification Techniques

Author(s): Agarwal A, Srivastava K, Puri SK, Chauhan PM

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Abstract A series of 2,4,6-trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial activity against Plasmodium falciparum. Of the 18 compounds synthesized, 14 compounds showed MIC in the range of 0.25-2 microg/mL. These compounds are in vitro several fold more active than pyrimethamine. This article was published in Bioorg Med Chem and referenced in Mass Spectrometry & Purification Techniques

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