alexa Synthesis of β-amino acid derivatives via copper-catalyzed asymmetric 1,4-reduction of β-(acylamino)acrylates.


Medicinal Chemistry

Author(s): Wu Y, Qi SB, Wu FF, Zhang XC, Li M,

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Abstract A new set of reaction conditions has been established to facilitate the copper-catalyzed enantioselective 1,4-reduction of β-(acylamino)acrylates toward a selection of β-alkyl-β-amino acid derivatives in high yields and with uniformly high ee values (up to 99\%) irrespective of the use of (E)- or (Z)-substrates. This article was published in Org Lett and referenced in Medicinal Chemistry

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