Author(s): Veinberg G, Shestakova I, Vorona M, Kanepe I, Lukevics E
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Abstract 6-alkylidenepenicillanate sulfoxides and sulfones were synthesized on the base of 6-oxopenicillanate esters. The targeted splitting of their thiazolidine ring led to the formation of 3-alkylidene substituted 4-heteryldithio and 4-methylsulfonyl azetidin-2-ones. Some of mono and bicyclic beta-lactams revealed potent cytotoxic properties towards monolayer tumor cells in <10-microM concentrations.
This article was published in Bioorg Med Chem Lett
and referenced in Medicinal Chemistry