Author(s): Haldar MK, Scott MD, Sule N, Srivastava DK, Mallik S
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Abstract The syntheses of a new class of barbiturate-based inhibitors for human and Escherichia Coli methionine aminopeptidase-1 (MetAP-1) are described. Some of the synthesized inhibitors show selective inhibition of the human enzyme with high potency.
This article was published in Bioorg Med Chem Lett
and referenced in Medicinal Chemistry