alexa Synthesis of digalactosyl diacylglycerols and their structure-inhibitory activity on human lanosterol synthase.
Pharmaceutical Sciences

Pharmaceutical Sciences

Biochemistry & Pharmacology: Open Access

Author(s): Tanaka R, Sakano Y, Nagatsu A, Shibuya M, Ebizuka Y,

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Abstract Digalactosyl and monogalactocyl diacylglycerols (DGDG and MGDG), which were identified as anti-hyperlipemia active components in Colocasia esculenta (Taro), were synthesized. The inhibitory activity of DGDG, MGDG and related compounds on human lanosterol synthase was evaluated as anti-hyperlipemic activity. DGDG with two myristoyl groups at both sn-1 and sn-2 positions and with an oleoyl group at the sn-1 position showed the most potent activity. This article was published in Bioorg Med Chem Lett and referenced in Biochemistry & Pharmacology: Open Access

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