Author(s): Geoffroy P, Ressault B, Marchioni E, Miesch M
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Abstract 14β-hydroxy pregnane glycosides extracted from Hoodia gordonii, a succulent plant isolated from Apocynaceae are suggested to have appetite suppressant properties in animals and humans. However, limited reports on biological studies concerning the appetite suppressant properties are available in the open literature. One reason for that is the poor availability of these glycosteroids because H. gordonii is a protected plant and the yield of extraction lies between 0.003\% and 0.02\%. Starting from 3α,12α-diacetoxy-pregnanone 1, we disclose in this report the synthesis of Hoodigogenin A, the aglycone of the natural 14β-hydroxy pregnane glycosides extracted from H. Gordonii. Copyright © 2011 Elsevier Inc. All rights reserved.
This article was published in Steroids
and referenced in Journal of Steroids & Hormonal Science