Author(s): Xu LL, Zheng CJ, Sun LP, Miao J, Piao HR
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Abstract In the present study, a series of 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties were synthesized and their antimicrobial activities were tested against various Gram-positive and Gram-negative bacteria. 1,3-diaryl-4-formylpyrazoles were synthesized as key intermediates following a Vilsmeier-Haack strategy. Several compounds with an MIC of 2 μg/mL, exhibited stronger antibacterial activity against the methicillin-resistant Staphylococcus aureus (MRSA) than the controls. None of the compounds showed any activity against Gram-negative bacteria. Copyright © 2012 Elsevier Masson SAS. All rights reserved.
This article was published in Eur J Med Chem
and referenced in Medicinal Chemistry