alexa Synthesis of novel antitumoural analogues of dysidiolide from ent-halimic acid.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Applied Pharmacy

Author(s): Marcos IS, Escola MA, Moro RF, Basabe P, Diez D,

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Abstract Several sesterterpenolides analogues of dysidiolide have been synthesized and their in vitro antitumoural activity against human HeLa, A549, HT-29 and HL-60 carcinoma cells is presented. The proliferation inhibition data showed a significant antitumour activity of the compounds 1b, 2a, 2b, 3a, 3b, 4a, 4b, 5, inhibiting proliferation of distinct cancer cell types with an IC(50) in the low micromolar range. This article was published in Bioorg Med Chem and referenced in Journal of Applied Pharmacy

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