alexa Synthesis of some new S-triazine based chalcones and their derivatives as potent antimicrobial agents.
Chemical Engineering

Chemical Engineering

Mass Spectrometry & Purification Techniques

Author(s): Solankee A, Kapadia K, Ana Ciri, Sokovi M, Doytchinova I,

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Abstract Base catalysed condensation of ketone 5 with different aldehydes give chalcones, 2.4-bis-(phenylamino)-6-[4'-{3''-(4'''-substituted phenyl/2'''-furanyl/2'''-thienyl)-2''-propenon-1''-yl}phenylamino]-s-thriazines 6a-e. These chalcones on cyclization with hydrazine hydrate in the presence of glacial acetic acid, guanidine nitrate in the presence of alkali and malononitrile in the presence of ammonium acetate give the corresponding acetylpyrazolines 7a-e, aminopyrimidines 8a-e and cyanopyridines 9a-e respectively. The products 6a-e, 7a-e, 8a-e and 9a-e were fully characterized by spectroscopic and elemental analysis and also tested for antibacterial activity. Copyright 2009 Elsevier Masson SAS. All rights reserved. This article was published in Eur J Med Chem and referenced in Mass Spectrometry & Purification Techniques

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