alexa Synthesis, spectral studies and antimicrobial activities of some 2-naphthyl pyrazoline derivatives.


Chemical Sciences Journal

Author(s): Sakthinathan SP, Vanangamudi G, Thirunarayanan G

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Abstract A series of 2-naphthyl pyrazolines were synthesized by the cyclization of 2-naphthyl chalcones and phenylhydrazine hydrochloride in the presence of sodium acetate. The yields of pyrazoline derivatives are more than 80\%. The synthesized pyrazolines were characterized by their physical constants, IR, (1)H, (13)C and MS spectra. From the IR and NMR spectra the C=N (cm(-1)) stretches, the pyrazoline ring proton chemical shifts (ppm) of δ(Ha), H(b) and H(c) and also the carbon chemical shifts (ppm) of δC=N are correlated with Hammett substituent constants, F and R, and Swain-Lupton's parameters using single and multi-regression analyses. From the results of linear regression analysis, the effect of substituents on the group frequencies has been predicted. The antimicrobial activities of all synthesized pyrazolines have been studied. Copyright © 2012 Elsevier B.V. All rights reserved. This article was published in Spectrochim Acta A Mol Biomol Spectrosc and referenced in Chemical Sciences Journal

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