alexa Synthetic cinnamylphenol derivatives as cancer chemopreventive agents.
Chemistry

Chemistry

Natural Products Chemistry & Research

Author(s): Ito C, Itoigawa M, Kanematsu T, Imamura Y, Tokuda H,

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Abstract Several substituted cinnamylphenol (1,3-diphenylpropene) derivatives were synthesized and tested for their inhibitory activities against in vitro Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The prenylated cinnamylphenols were found to show remarkably potent activity. Furthermore, prenylated cinnamylphenols (19 and 25) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These results indicate that some prenylated cinnamylphenols might be valuable as potential cancer chemopreventive agents (anti-tumor promoters). This article was published in Eur J Med Chem and referenced in Natural Products Chemistry & Research

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