Author(s): Kamena F, Tamborrini M, Liu X, Kwon YU, Thompson F,
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Abstract Parasite glycosylphosphatidylinositol (GPI) is an important toxin in malaria disease, and people living in malaria-endemic regions often produce high levels of anti-GPI antibodies. The natural anti-GPI antibody response needs to be understood to aid the design of an efficient carbohydrate-based antitoxin vaccine. We present a versatile approach based on a synthetic GPI glycan array to correlate anti-GPI antibody levels and protection from severe malaria.
This article was published in Nat Chem Biol
and referenced in Journal of Glycomics & Lipidomics