alexa Systematic review and meta-analysis of the association between P53 codon 72 polymorphism and colorectal cancer
Oncology

Oncology

Journal of Carcinogenesis & Mutagenesis

Author(s): Tang NP, Wu YM, Wang B, Ma J

Abstract Share this page

Background

A number of studies has evaluated the association between P53 codon 72 polymorphism and colorectal cancer. However, results were inconsistent. To clarify the role of this polymorphism in colorectal cancer, we conducted a meta-analysis on this topic.

Methods

Two authors independently searched the PubMed and EMBASE database from 1966 to January 2010 for studies regarding the association of P53 codon 72 polymorphism with colorectal cancer. Summary odds ratios with their corresponding 95% confidence intervals were calculated by using random-effects model.

Results

The combined results showed that P53 codon 72 variant genotypes were not associated with colorectal cancer risk when compared to Arg/Arg genotype (Pro/Pro: OR = 1.02, 95% CI = 0.80–1.29; Arg/Pro: OR = 1.00, 95% CI = 0.86–1.16; Pro allele: OR = 1.00, 95% CI = 0.86–1.17). When stratifying for study population, design and cancer location, no statistically significant results were observed either.

Conclusion

Our data indicate that the P53 codon 72 polymorphism may be not associated with colorectal cancer risk.

This article was published in Eur J Surg Oncol and referenced in Journal of Carcinogenesis & Mutagenesis

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