alexa Systemic delivery of synthetic microRNA-451 is an effective therapeutic strategy for the treatment of lung cancer.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Lou B, Zhou X

Abstract Share this page

Abstract MicroRNAs (miRNAs) can function as tumor suppressors and may provide an efficient strategy for the eradication of cancer. Specific miRNAs can be reintroduced into tumor cells to complement loss of tumor suppression activities. The aim of the present study was to develop miRNA delivery formulation using synthesized miR-451. miR-451 was detected using RT-PCR and tissues were analyzed using immunohistochemical analysis. miRNA delivery formulation proved to be effective either locally or systemically. miR-451 accumulation became evident in tumor cells and exerted an anti-proliferative function. The intravenous delivery of formulated miR-451 did not induce any deregulation in the cytokine levels and liver enzymes. Taken together, the results provide insight into the concept of the systemic delivery of synthetic mimics for tumor suppressor miR-451 and provide potential implications for miRNA therapy in clinical practice. This article was published in Int J Mol Med and referenced in Pharmaceutica Analytica Acta

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords