Author(s): Querec TD, Akondy RS, Lee EK, Cao W, Nakaya HI,
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Abstract A major challenge in vaccinology is to prospectively determine vaccine efficacy. Here we have used a systems biology approach to identify early gene 'signatures' that predicted immune responses in humans vaccinated with yellow fever vaccine YF-17D. Vaccination induced genes that regulate virus innate sensing and type I interferon production. Computational analyses identified a gene signature, including complement protein C1qB and eukaryotic translation initiation factor 2 alpha kinase 4-an orchestrator of the integrated stress response-that correlated with and predicted YF-17D CD8(+) T cell responses with up to 90\% accuracy in an independent, blinded trial. A distinct signature, including B cell growth factor TNFRS17, predicted the neutralizing antibody response with up to 100\% accuracy. These data highlight the utility of systems biology approaches in predicting vaccine efficacy.
This article was published in Nat Immunol
and referenced in Journal of Vaccines & Vaccination