Author(s): Wood AJ, Lo TW, Zeitler B, Pickle CS, Ralston EJ,
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Abstract Evolutionary studies necessary to dissect diverse biological processes have been limited by the lack of reverse genetic approaches in most organisms with sequenced genomes. We established a broadly applicable strategy using zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) for targeted disruption of endogenous genes and cis-acting regulatory elements in diverged nematode species.
This article was published in Science
and referenced in Journal of Microbial & Biochemical Technology