alexa Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Cho SW, Kim S, Kim JM, Kim JS, Cho SW, Kim S, Kim JM, Kim JS

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Abstract We employ the CRISPR-Cas system of Streptococcus pyogenes as programmable RNA-guided endonucleases (RGENs) to cleave DNA in a targeted manner for genome editing in human cells. We show that complexes of the Cas9 protein and artificial chimeric RNAs efficiently cleave two genomic sites and induce indels with frequencies of up to 33\%. This article was published in Nat Biotechnol and referenced in Journal of AIDS & Clinical Research

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