alexa Taste masking of bitter drug powder without loss of bioavailability by heat treatment of wax-coated microparticles.
Psychiatry

Psychiatry

Journal of Addiction Research & Therapy

Author(s): Sugao H, Yamazaki S, Shiozawa H, Yano K

Abstract Share this page

Abstract Indeloxazine hydrochloride (IDX), a cerebral activator, has a bitter astringent taste. To prepare powders of IDX without this bitter taste, microparticles (median diameter, 130 microns) of IDX were coated with a mixture comprising hydrogenated oil and surfactants in a fluidized bed using the side-spray method. Drug release from the resulting coated particles was significantly delayed. Dissolution rate was remarkably enhanced, however, by heat-treating the coated particles at a temperature above the melting point of the surfactant in the coated layer. The results of differential scanning calorimetry measurements show that part of the surfactant in the coated layer exists separately. Further, surface changes in the coated layer before and after heat treatment showed that this enhancement of dissolution rate was due to rediffusion of the surfactant in the coated layer followed by melting of the surfactant. This effect allows the design of powders of IDX which release the drug quickly and with bioequivalence to the commercial IDX 20 mg tablets while sufficiently suppressing the bitter taste. This article was published in J Pharm Sci and referenced in Journal of Addiction Research & Therapy

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords