alexa T-cell regulation of peripheral tolerance and immunity: the potential role for Notch signalling.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Stem Cell Research & Therapy

Author(s): Hoyne GF, Dallman MJ, Lamb JR

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Abstract Recognition of antigen by T cells in the periphery may lead either to the generation of productive immunity or the induction of tolerance. These two functional outcomes are a consequence of distinct pathways of T-cell differentiation. T cells are selected to become regulatory cells and their function is to maintain homeostasis with the immune system. In this review we discuss the cell-fate decisions that T cells might make allowing them to promote immunity or induce tolerance in the context of the role that Notch signalling may play in this process.
This article was published in Immunology and referenced in Journal of Stem Cell Research & Therapy

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