alexa Tec family kinases in inflammation and disease.
Genetics & Molecular Biology

Genetics & Molecular Biology

Gene Technology

Author(s): Horwood NJ, Urbaniak AM, Danks L

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Abstract Over the last decade, the Tec family of nonreceptor tyrosine kinases (Btk, Tec, Bmx, Itk, and Rlk) have been shown to play a key role in inflammation and bone destruction. Bruton's tyrosine kinase (Btk) has been the most widely studied due to the critical role of this kinase in B-cell development and recent evidence showing that blocking Btk signaling is effective in ameliorating lymphoma progression and experimental arthritis. This review will examine the role of TFK in myeloid cell function and the potential of targeting these kinases as a therapeutic intervention in autoimmune disorders such as rheumatoid arthritis. This article was published in Int Rev Immunol and referenced in Gene Technology

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