alexa Tec family kinases: Itk signaling and the development of NKT αβ and γδ T cells.


Journal of Clinical & Cellular Immunology

Author(s): Qi Q, Kannan AK, August A

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Abstract The Tec family tyrosine kinase interleukin-2 inducible T-cell kinase (Itk) is predominantly expressed in T cells and has been shown to be critical for the development, function and differentiation of conventional αβ T cells. However, less is known about its role in nonconventional T cells such as NKT and γδ T cells. In this minireview, we discuss evidence for a role for Itk in the development of invariant NKT αβ cells, as well as a smaller population NKT-like γδ T cells. We discuss how these cells take what could be the same signaling pathway regulated by Itk, and interpret it to give different outcomes with regards to development and function. © 2011 The Authors Journal compilation © 2011 FEBS. This article was published in FEBS J and referenced in Journal of Clinical & Cellular Immunology

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