alexa Telomeres and telomerase dance to the rhythm of the cell cycle.
Chemistry

Chemistry

Medicinal Chemistry

Author(s): LondooVallejo JA, Wellinger RJ

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Abstract The stability of the ends of linear eukaryotic chromosomes is ensured by functional telomeres, which are composed of short, species-specific direct repeat sequences. The maintenance of telomeres depends on a specialized ribonucleoprotein (RNP) called telomerase. Both telomeres and telomerase are dynamic entities with different physical behaviors and, given their substrate-enzyme relation, they must establish a productive interaction. Regulatory mechanisms controlling this interaction are key missing elements in our understanding of telomere functions. Here, we review the dynamic properties of telomeres and the maturing telomerase RNPs, and summarize how tracking the timing of their dance during the cell cycle will yield insights into chromosome stability mechanisms. Cancer cells often display loss of genome integrity; therefore, these issues are of particular interest for our understanding of cancer initiation or progression. Copyright © 2012 Elsevier Ltd. All rights reserved. This article was published in Trends Biochem Sci and referenced in Medicinal Chemistry

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