alexa Telomeres: no end in sight
Oncology

Oncology

Journal of Carcinogenesis & Mutagenesis

Author(s): Blackburn EH

Abstract Share this page

Why
do
eukaryotic
chromosomes
end
the
way
they
do?
One
basic
function
of
teiomeres,
the
ends
of
chromo-
somes,
is
to
preserve
themselves;
they
allow
replen-
ishment
of
the
chromosomai
DNA
termini
by
an
indepen-
dent
mechanism
of
DNA
synthesis,
to
make
up
for
the
incomplete
replication
of
the
5’
end
of
each
chromosomal
DNA
strand
by
the
primary
cellular
DNA
replication
ma-
chinery.
But
why
is
a
special
DNA
sequence
needed
at
teiomeres?
Obsetvations
of
teiomere
behavior
indicate
that
teiomeres
play
multiple
roles,
some
new
and
surpris-
ing.
This
minireview
highlights
recent
work
that
throws
into
sharp
relief
the
question
of
why
a
specific
DNA
sequence
is
required
to
stabilize
chromosomes.
The
Correct
Telomeric
DNA

Sequen

  • To read the full article Visit
  • Open Access
This article was published in Cell. and referenced in Journal of Carcinogenesis & Mutagenesis

Relevant Expert PPTs

Relevant Speaker PPTs

  • Recep Çelik
    GIS based assessment effect of irrigation on groundwater level changes in agricultural areas: A case study on the Bismil plain in the Upper Tigris Basin
    PPT Version | PDF Version
  • K Sofia Mercy
    Incarcerated vaginal pessary- A report of two cases
    PPT Version | PDF Version
  • B Saranya
    Clinical presentation of ectopic pregnancy presented as PID – A case report
    PPT Version | PDF Version
  • M.KAAVYA
    PERIPARTUM CARDIOMYOPATHY-A CASE REPORT
    PPT Version | PDF Version
  • Werner Boecker
    Syringomatous tumour of the nipple and low-grade adenosquamous carcinoma: Evidence for a common origin
    PPT Version | PDF Version
  • Jim Polarine
    Case studies of human fl ora and spore contamination in clean rooms
    PPT Version | PDF Version
  • Mapitsi S Thantsha
    In vitro antagonistic effects of Listeria adhesion protein (LAP)-expressing Lactobacillus casei against Listeria monocytogenes and Salmonella Typhimurium Copenhagen
    PPT Version | PDF Version
  • Tibor Tot
    Multiparameter characterization of breast carcinoma: subgross, microscopy, proteins, and genes
    PPT Version | PDF Version
  • Vicente Marco
    Changes in breast cancer pathology reports after second opinion
    PPT Version | PDF Version
  • Ali Can Yilmaz
    Ali-Can-Yilmaz-Çukurova-University-Turkey-GRNN-and-MFFNN-Models-for-Energy-Equivalent-Speed-Prediction-and-Fault-Rate-Determination-of-Involvements-in-Traffic-Accidents-A-case
    PPT Version | PDF Version
  • Fathia El Sharkawi
    The effect of PTEN and TRAIL genes loaded on nanoparticles on hepatocellular carcinoma
    PPT Version | PDF Version
  • Yosef Yarden
    Classically, the 3’untranslated region (3’UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3’UTR alone, without all other elements in mRNA such as 5’UTR and coding region. The importance of independent 3’UTR RNA (referred as I3’UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3’UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3’UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3’UTR were important for its tumor suppression activity. Then, the C/EBP 3’UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3’UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3’UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990’s to 2000’s, world scientists found several 3’UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3’UTR regions, although the existence of their transcribed products as independent 3’UTR RNAs is still to be confirmed. Our studies indicate that the independent 3’UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
    PPT Version | PDF Version
  • Arny L Blanchard
    Long-term environmental studies and stewardship in Alaska: A case study from Port Valdez
    PPT Version | PDF Version
  • Abdalla Omar
    Study of Some Egyptian Plants of Potential Use in Some Cases of Hepatic Disorders
    PPT Version | PDF Version
  • Devathri Nanayakkara
    Context specific role of deubiquitylase enzyme, USP9X in oral squamous cell carcinoma
    PPT Version | PDF Version

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords